About RNA fold classification
RR3DD(an RMscore-based RNA 3D classification Database) is a database which classified all RNAs into individual folds. For each cluster, the "center" RNA is chosen as the representative structure and defined as an RNA fold. There are 510 folds in RR3DD at first version. In the current version, there are 780 RNA folds that include 7466 RNA chains from PDB-format structures and 6135 RNA chains from mmCIF-format structures in PDB. RNAs are classified through their global structural similarity generated by RMalign. The database offers all folds to users, which could be used as templates for RNA 3D structure modeling probably. we analyzed all tRNAs, G-quadruplex structures in our database. And RR3DD is mapped to RFAM database, which is essential for us to understand the function of the RNA. At last, the classification and fold will be evolved with more data available.
References:
1.Jinfang Zheng, Juan Xie, Xu Hong and Shiyong Liu. RMalign: an RNA structural alignment tool based on a novel scoring function RMscore. BMC Genomics, 8 April 2019 [PubMed] [PDF] Details
2.Xu Hong, Jinfang Zheng, Juan Xie, Xiaoxue Tong, Xudong Liu, Qi Song, Sen Liu and Shiyong Liu. RR3DD: an RNA global structure-based RNA three-dimensional structural classification database. RNA biology,19,Oct 2021 [PubMed] [PDF] Details